SYNTHESES OF IMIDAZOLE-ACRIDINE CONJUGATES AS RIBONUCLEASE-A MIMICS

Authors
LORENTE A ESPINOSA JF FERNANDEZSAIZ M LEHN JM WILSON WD ZHONG YY
Citation
A. Lorente et al., SYNTHESES OF IMIDAZOLE-ACRIDINE CONJUGATES AS RIBONUCLEASE-A MIMICS, Tetrahedron letters, 37(25), 1996, pp. 4417-4420
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
25
Year of publication
1996
Pages
4417 - 4420
Database
ISI
SICI code
0040-4039(1996)37:25<4417:SOICAR>2.0.ZU;2-3
Abstract
As a result of efforts to mimic the activity of RNase A we report the syntheses of two novel molecules 1 and 2 containing imidazole residues conjugated to an acridine, a well known intercalator and as such thes e molecules simultaneously have substrate recognition and potential ca talytic ability. t-RNA cleavage by I and 2 is reported. Copyright (C) 1996 Elsevier Science Ltd