INFLUENCE OF ISOVOLEMIC AND HYPERVOLEMIC HEMODILUTION WITH HYDROXYETHYL STARCH-200 0.5 10-PERCENT ON BLOOD FLUIDITY AND INTRAMUSCULAR OXYGEN-PRESSURE IN PATIENTS WITH PERIPHERAL OCCLUSIVE ARTERIAL-DISEASE/

In a Cross-Over study the influence of a hyper- and isovolaemic haemod ilution on blood fluidity, blood flow in the macro- and microcirculati on as well as on tissue oxygen tension (M. tibialis anterior) was inve stigated in n=8 patients with arterial occlusive disease stage II acco rding to Fontaine. In both cases 500 ml hydroxyethyl starch (HES 200/0 .5 10%) were infused within a period of 60 minutes. In case of isovola emic haemodilution 250 ml hydroxyethyl starch were given over 20 minut es, then 250 mi blood withdrawn (over 10 min), 250 ml hydroxyethyl sta rch given and at least again 250 ml blood withdrawn. Prior to and 1, 3 , 6 and 24 hours after haemodilution the rheological parameters (haema tocrit, plasma viscosity, erythrocyte aggregation, erythrocyte rigidit y and spontaneous thrombocyte aggregation) as well. as the oxygen part ial pressure histogram in the tibialis anterior muscle were measured. Blood pressure and heart rate did not change during and after haemodil ution. Painfree walking distance increased after isovolaemic (105% aft er 1 h) more than after hypervolaemic (31% after 1 h) haemodilution. T he fluidity of blood shows a significant improvement only after isovol aemic haemodilution; plasma viscosity decreased about 5%, erythrocyte aggregation about 22% and haematocrit about 16%. 24 h after haemodilut ion the rheological parameters reached initial values. The intramuscul ar oxygen partial pressure increased after hypervolaemic haemodilution about 35%, after isovolaemic haemodilution about 45%.