END-STAGE MYOGLOBINURIC RENAL-FAILURE DUE TO LOVASTATIN THERAPY IN PREEXISTING CHRONIC RENAL-INSUFFICIENCY - A CASE-REPORT

Atraumatic rhabdomyolysis with consecutive oliguric renal failure occu rred in a 67-year-old man with chronic renal insufficiency in the pre- dialysis phase after four years of therapy with lovastatin without com plications. Diuresis remained low after normalization of the muscle en zymes, and the patient required chronic hemodialysis. This case report shows that lovastatin-associated rhabdomyolysis with consecutive myog lobinuric renal failure can be seen also after longstanding lovastatin therapy. In pre-existing renal insufficiency this can lead to earlier requirement of chronic dialysis treatment.