TRANSCRIPTIONAL REGULATION OF GLUT4 GENE-EXPRESSION

The in-vivo expression of the muscle/adipose-specific GLUT4 under cond itions of relative as fasting and streptozotocin (STZ)-induced diabete s. These alterations in GLUT4 transcription occur in a tissue-specific manner with a significantly greater reduction in cardiac and adipose tissue compared to skeletal muscle. To identify the cis-DNA elements r esponsible for the complex pattern of tissue-specific and nutritional/ metabolic regulation, transgenic mice have successfully been used to e xamine the expression of the human GLUT4 gene. These data have demonst rated the presence of at least two functional regions required for the appropriate tissue-specific and nutritional/metabolic regulation of d emonstrated the presence of a major transcript at GLUT4 gene expressio n. (C) 1996 Academic Press Ltd