PHYSIOLOGICALLY-BASED PHARMACOKINETIC MOD ELING IN VETERINARY-MEDICINE

The physiologically-based pharmacokinetic modelling is useful in veter inary medicine. This model can predict the drug tissular concentration s for different treatments. The development of the physiologically-bas ed pharmacokinetic models consists on three steps. The first is the mo del representation with a diagram and the mathematical equations who d escribe the different interrelationships. Then, the mathematical equat ions parameters must be obtain. There are physiological, physicochemic al and biochemical parameters. The last step is the model validation. Some applications of the physiologically-based pharmacokinetic model a re given in this review.