EXPRESSION OF ANTIGENS ASSOCIATED WITH THE INDIVIDUAL STAGES OF THE INFLAMMATORY RESPONSE IN CHILD AND ADULT AS A POSSIBLE DISTINCTIVE METHOD FOR RECURRENT AND CHRONIC TONSILLITIS
M. Bussi et al., EXPRESSION OF ANTIGENS ASSOCIATED WITH THE INDIVIDUAL STAGES OF THE INFLAMMATORY RESPONSE IN CHILD AND ADULT AS A POSSIBLE DISTINCTIVE METHOD FOR RECURRENT AND CHRONIC TONSILLITIS, International journal of pediatric otorhinolaryngology, 35(3), 1996, pp. 243-250
Monoclonal antibodies (MoAbs) specific for the antigens associated wit
h each stage of an inflammatory response were assayed with tonsillar m
ononuclear cells (TMNG). MoAbs BMA 27 E 10 and BMA 4 D 10 were used as
markers for the early stages, BMA RM 3/1 for the intermediate stage,
BMA 25 F 9 for the late Stage, and BMA G 16/1 for the chronic stage. T
MNC were obtained from patients operated for (1) recurrent tonsillitis
with hypertrophy caused by common flora (children); (2) an indication
for surgery for chronic tonsillitis in adults; (3) patients who were
'warm' tonsillectomized for a second peri-tonsillar phlegmon. Our resu
lts are presented and discussed in the light of their possible clinica
l significance. Our findings indicate that clinical chronic tonsilliti
s in the adult really is such. In the adults studied there was a high
expression of antigens which is associated with the chronic stages, wh
ile the low expression of antigens is associated with the intermediate
stage and an even lower antigen expression indicates the acute stage.
In children what is considered to be chronic tonsillitis may perhaps
be more correctly regarded as an expression of recurrent inflammation.