ARREST OF SEIZURE PROGRESSION DURING ELECTRICAL KINDLING IN GUINEA-PIGS WITH PRIOR PENTYLENETETRAZOL-INDUCED CONVULSIONS

A number of comparative differences in the kindling phenomenon have be en observed between guinea-pigs and rats. These differences likely ref lect different mechanisms underlying brain plasticity. In this study, guinea-pigs were used to examine the kindling transfer phenomenon betw een peripheral pentylenetetrazol injection and electrical kindling of the amygdala. The changes in afterdischarge characteristics and behavi oural seizures during electrical kindling were compared between animal s that had experienced three PTZ-induced convulsions and PTZ-naive con trols. We report that on the first electrical kindling session the PTZ -convulsed guinea-pigs displayed lower AD thresholds, enhanced AD dura tions and seizures, but that their seizures did not progress with repe ated daily kindling stimulation.