EFFECT OF INHALED HEPARIN ON ALLERGEN-INDUCED EARLY AND LATE ASTHMATIC RESPONSES IN PATIENTS WITH ATOPIC ASTHMA

Citation
Z. Diamant et al., EFFECT OF INHALED HEPARIN ON ALLERGEN-INDUCED EARLY AND LATE ASTHMATIC RESPONSES IN PATIENTS WITH ATOPIC ASTHMA, American journal of respiratory and critical care medicine, 153(6), 1996, pp. 1790-1795
Citations number
36
Categorie Soggetti
Emergency Medicine & Critical Care","Respiratory System
ISSN journal
1073449X
Volume
153
Issue
6
Year of publication
1996
Pages
1790 - 1795
Database
ISI
SICI code
1073-449X(1996)153:6<1790:EOIHOA>2.0.ZU;2-2
Abstract
Heparin possesses anti-inflammatory properties, which appeared to be d ependent on the dose, timing, and the route of administration in anima l studies. in asthma, a single dose of inhaled heparin only slightly r educed the early asthmatic response (EAR) but failed to protect agains t the late asthmatic response (LAR) to inhaled allergen. We studied th e effect of multiple doses of inhaled heparin on the EAR and LAR to in haled house-dust mite extract in eight stable asthmatics in a two-peri od, randomized, double-blind, crossover study. During both study perio ds, a standardized allergen challenge was performed and PC20 histamine was measured 24 h before and 24 h postallergen, Five doses of unfract ionated heparin sodium (1,000 U/kg/dose) or placebo were inhaled 90 an d 30 min preallergen, and 2, 4, and 6 h postallergen. Airway response was measured by FEV(1), and the EAR (0-3 h) and LAR (3-10 h) were expr essed as corresponding areas under the time-response curves (AUC). The acute effects of heparin and placebo on baseline FEV(1) were not diff erent (p > 0.07). Although not reaching significance, heparin attenuat ed the EAR by an average of 40% (mean AUC(0-3) +/- SEM: 29.5 +/- 6.0 [ placebo] and 17.8 +/- 5.5% fall . h [heparin]; p = 0.08), while it sig nificantly reduced the LAR by an average of 36% (AUC(3-10) +/- SEM: 16 9.3 +/- 20.0 [placebo] and 109.1 +/- 23.6% fall . h [heparin]; p = 0.0 05). We conclude that inhaled heparin reduces the LAR to allergen in a sthmatic subjects, which may be due to its anti-inflammatory activity. Our finding suggests that heparin may have potential as anti-asthma t herapy.