PHARMACOKINETIC PROFILE OF TOPIRAMATE IN COMPARISON WITH OTHER NEW ANTIEPILEPTIC DRUGS

Antiepileptic drugs (AEDs)in broad use today have a number of pharmaco kinetic liabilities, including a propensity for clinically meaningful drug interactions. Therefore, new AEDs with improved pharmacokinetic c haracteristics would be welcomed. The pharmacokinetic profiles of six newer AEDs-topiramate (TPM), gabapentin (GBP), vigabatrin (VGB), lamot rigine (LTG), oxcarbazepine (OCBZ), and felbamate-were reviewed. Some of these AEDs offer an improvement in one or more pharmacokinetic para meters compared with traditional AEDs, with TPM, GBP, VGB, and OCBZ de monstrating the most advantageous overall pharmacokinetic profiles.