ANTITUMOR GERMACRANOLIDES FROM ANVILLEA-GARCINII

The aerial parts of Anvillea garcinii yielded two new germacranolides, 9 alpha-hydroxy-1 beta,10 alpha-epoxyparthenolide (4) and parthenolid -9-one (5), in addition to the-known 9 alpha-hydroxyparthenolide (1), 9 beta-hydroxyparthenolide (2), and 9 beta-hydroxy-1 beta,10 alpha-epo xyparthenolide (3). The structures of the new compounds were elucidate d from their spectral data (IR, MS, H-1- and C-13-NMR, H-1-H-1 COSY, a nd H-1-C-13 HETCOR) and by chemical derivatization. The hitherto unrep orted C-13-NMR data and carbon atom assignments of the previously isol ated lactones 1, 2, and 3 were given. The in-vitro antitumor and anti- HIV activities were evaluated for the isolated compounds.