BARBAMIDE, A CHLORINATED METABOLITE WITH MOLLUSCICIDAL ACTIVITY FROM THE CARIBBEAN CYANOBACTERIUM LYNGBYA-MAJUSCULA

The lipid extract from a Curacao collection of the marine cyanobacteri um Lyngbya majuscula was toxic to the mollusc Biomphalaria glabrata. S ubsequent bioassay-guided fractionation of this extract yielded a nove l Lipopeptide, barbamide, as the active compound (LC(100) = 10 mu g/mL ). The structure of barbamide was determined by spectroscopic methods and was found to contain several unique structural features, including a trichloromethyl group and the methyl enol ether of a beta-keto amid e.