THE RELEASE OF CLINDAMYCIN PHOSPHATE FROM A SUSPENSION OF DIFFERENT TYPES OF LIPOSOMES AND SELECTED TOPICAL DOSAGES FORMS

A Franz diffusion cells system was used to determine the release rate profile of clindamycin phosphate. Different types of liposomes contain ing clindamycin phosphate were prepared and the steady-state release o f the drug, through a semipermeable synthetic membrane, was determined . The highest retention of clindamycin phosphate was seen from a suspe nsion of multilamellar liposomes containing 1% clindamycin phosphate. Hydrogels, of acceptable consistency for topical use, were developed a nd used as carriers for a suspension of reverse-phase liposomes contai ning clindamycin phosphate. Increased penetration of clindamycin phosp hate through a hairless mouse skin from a liposomes-containing vehicle compared with the permeation of the drug in a phosphate buffer was no t observed.