Hb. Arnardottir et al., THE RELEASE OF CLINDAMYCIN PHOSPHATE FROM A SUSPENSION OF DIFFERENT TYPES OF LIPOSOMES AND SELECTED TOPICAL DOSAGES FORMS, International journal of pharmaceutics, 134(1-2), 1996, pp. 71-77
A Franz diffusion cells system was used to determine the release rate
profile of clindamycin phosphate. Different types of liposomes contain
ing clindamycin phosphate were prepared and the steady-state release o
f the drug, through a semipermeable synthetic membrane, was determined
. The highest retention of clindamycin phosphate was seen from a suspe
nsion of multilamellar liposomes containing 1% clindamycin phosphate.
Hydrogels, of acceptable consistency for topical use, were developed a
nd used as carriers for a suspension of reverse-phase liposomes contai
ning clindamycin phosphate. Increased penetration of clindamycin phosp
hate through a hairless mouse skin from a liposomes-containing vehicle
compared with the permeation of the drug in a phosphate buffer was no
t observed.