ION-SELECTIVE ELECTRODE FOR SALICYLATE ASSAY IN BLOOD-SERUM

A salicylate-selective membrane electrode made with heptyl-4-trifluoro acetylbenzoate as a neutral carrier was successfully applied for the d etermination of salicylate in blood serum. This procedure is advantage ous because the free concentration of the drug in serum can be determi ned without sample preparation. The free salicylate concentrations det ermined-by the ion-selective electrode compared to those obtained by c onventional colorimetry gave a linear correlation coefficient 0.997 in the salicylate concentration range 0.1-2.5 mM.