A PROTEIN AA-VARIANT DERIVED FROM A NOVEL SERUM AA PROTEIN, SAA1-DELTA, IN AN INDIVIDUAL FROM PAPUA-NEW-GUINEA

Authors
WESTERMARK P SLETTEN K WESTERMARK GT RAYNES J MCADAM KPWJ
Citation
P. Westermark et al., A PROTEIN AA-VARIANT DERIVED FROM A NOVEL SERUM AA PROTEIN, SAA1-DELTA, IN AN INDIVIDUAL FROM PAPUA-NEW-GUINEA, Biochemical and biophysical research communications, 223(2), 1996, pp. 320-323
Citations number
26
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
223
Issue
2
Year of publication
1996
Pages
320 - 323
Database
ISI
SICI code
0006-291X(1996)223:2<320:APADFA>2.0.ZU;2-J
Abstract
A major protein AA amyloid protein was purified and characterised from a Papua New Guinean individual. This AA protein differed from all pre viously characterised SAA variants by the combination of Ala52, Val57, Asn60, Phe68, Phe69 and Gly72. Since the prevalence of AA-amyloidosis is unusually high in Papua New Guinea this AAS must originate from a novel SAA delta which may represent a particularly amyloidogenic varia nt. (C) 1996 Academic Press, Inc.