SEVERE THROMBOSIS DURING TREATMENT WITH ETHINYLESTRADIOL FOR TALL STATURE

High-dose estradiol therapy for reduction of final height may be compl icated by severe side effects such as deep vein thrombosis. We report a 14.6-year-old girl with tall stature. In order to reduce final heigh t she was treated with ethinylestradiol and medroxyprogesterone. After arthroscopy she suffered acute deep venous thrombosis of her left leg . Despite being monitored at short intervals, coagulation parameters s uch as AT III and protein C indicated no development of thrombosis. Me dical height reduction with estrogen should be accompanied by heparini sation during longer-lasting periods of immobilisation.