AMAROGENTIN, A NATURALLY-OCCURRING SECOIRIDOID GLYCOSIDE AND A NEWLY RECOGNIZED INHIBITOR OF TOPOISOMERASE-I FROM LEISHMANIA-DONOVANI

Citation
S. Ray et al., AMAROGENTIN, A NATURALLY-OCCURRING SECOIRIDOID GLYCOSIDE AND A NEWLY RECOGNIZED INHIBITOR OF TOPOISOMERASE-I FROM LEISHMANIA-DONOVANI, Journal of natural products, 59(1), 1996, pp. 27-29
Citations number
40
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
ISSN journal
01633864
Volume
59
Issue
1
Year of publication
1996
Pages
27 - 29
Database
ISI
SICI code
0163-3864(1996)59:1<27:AANSGA>2.0.ZU;2-6
Abstract
A MeOH extract of Swertia chirata found to inhibit the catalytic activ ity of topoisomerase I of Leishmania donovani was subjected to fractio nation to yield three secoiridoid glycosides: amarogentin (1), amarosw erin (2), and sweroside (3). Amarogentin is a potent inhibitor of type I DNA topoisomerase from Leishmania and exerts its effect by interact ion with the enzyme, preventing binary complex formation.