ROLE OF OXYGEN RADICALS FORMED DURING THE FUNCTIONING OF THE REDOX CHAIN IN MEMBRANES IN DAMAGE TO NUCLEAR-DNA

Authors
PESKIN AV
Citation
Av. Peskin, ROLE OF OXYGEN RADICALS FORMED DURING THE FUNCTIONING OF THE REDOX CHAIN IN MEMBRANES IN DAMAGE TO NUCLEAR-DNA, Biochemistry, 61(1), 1996, pp. 47-52
Citations number
50
Categorie Soggetti
Biology
Journal title
Biochemistry → ACNP
ISSN journal
00062979
Volume
61
Issue
1
Year of publication
1996
Pages
47 - 52
Database
ISI
SICI code
0006-2979(1996)61:1<47:ROORFD>2.0.ZU;2-U
Abstract
Damage to nuclear DNA resulting from the incubation of isolated rat li ver nuclei in the presence of NADPH or NADH and ethylenediaminetetraac etic acid or diethylenetriaminepentaacetic acid or deferoxamine Fe2+ c omplexes was studied. Damage to DNA was analyzed by agarose electropho resis. The observed DNA damage was prevented by catalase but not super oxide dismutase. The mechanism of oxidizing damage to nuclear DNA duri ng the functioning of the membrane redox chain is discussed.