ABILITY OF DIFFERENT FLAVONOIDS TO INHIBIT THE PROCOAGULANT ACTIVITY OF ADHERENT HUMAN MONOCYTES

Authors
LALE A HERBERT JM AUGEREAU JM BILLON M LECONTE M GLEYE J
Citation
A. Lale et al., ABILITY OF DIFFERENT FLAVONOIDS TO INHIBIT THE PROCOAGULANT ACTIVITY OF ADHERENT HUMAN MONOCYTES, Journal of natural products, 59(3), 1996, pp. 273-276
Citations number
15
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
59
Issue
3
Year of publication
1996
Pages
273 - 276
Database
ISI
SICI code
0163-3864(1996)59:3<273:AODFTI>2.0.ZU;2-A
Abstract
Sixty-five natural flavonoids of various chemical classes were screene d for their ability to inhibit the procoagulant activity of adherent h uman monocytes stimulated by endotoxin and interleukin-1 beta in vitro . Eighteen of these compounds inhibited the interleukin-1 beta-induced expression of tissue factor on human monocytes, but the most active c ompound was a biflavonoid: hinokiflavone.