BIOACTIVE STEROIDAL ALKALOIDS FROM SOLANUM-UMBELLIFERUM

Authors
KIM YC CHE QM GUNATILAKA AAL KINGSTON DGI
Citation
Yc. Kim et al., BIOACTIVE STEROIDAL ALKALOIDS FROM SOLANUM-UMBELLIFERUM, Journal of natural products, 59(3), 1996, pp. 283-285
Citations number
13
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
59
Issue
3
Year of publication
1996
Pages
283 - 285
Database
ISI
SICI code
0163-3864(1996)59:3<283:BSAFS>2.0.ZU;2-S
Abstract
Bioassay-directed fractionation of the MeOH extract of Solanum umbelli ferum afforded solasodine (1), O-acetylsolasodine (2), and solasodine 3-O-beta-D-glucopyranoside (3). Alkaloids 1 and 2 exhibited significan t activity toward DNA repair-deficient yeast mutants, whereas 3 and th e synthetic analogues N-acetylsolasodine (4) and N,O-diacetylsolasodin e (5) were found to be inactive. Compounds 2 and 3 are new natural pro ducts.