ANTINEOPLASTIC AGENTS .340. ISOLATION AND STRUCTURAL ELUCIDATION OF BRYOSTATINS-16-18

Authors
PETTIT GR GAO F BLUMBERG PM HERALD CL COLL JC KAMANO Y LEWIN NE SCHMIDT JM CHAPUIS JC
Citation
Gr. Pettit et al., ANTINEOPLASTIC AGENTS .340. ISOLATION AND STRUCTURAL ELUCIDATION OF BRYOSTATINS-16-18, Journal of natural products, 59(3), 1996, pp. 286-289
Citations number
33
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
59
Issue
3
Year of publication
1996
Pages
286 - 289
Database
ISI
SICI code
0163-3864(1996)59:3<286:AA.IAS>2.0.ZU;2-3
Abstract
Separation of two trace cancer cell growth inhibitory (P388 leukemia) fractions from about 1000 kg of wet Gulf of Mexico Bugula neritina (Br yozoa) has led to the isolation of bryostatins 16-18 (2-4). A combinat ion of HRFABMS and high-field (400 MHz) H-1- and C-13-NMR spectral ana lyses were employed to assign the structures. The three new 20-desoxyb ryostatins 16 (2), 17 (3), and 18 (4) showed significant growth inhibi tory activity (P388 ED(50), 2, 9.3 x 10(-3) mu g/ mL, 3, 1.9 x 10(-2) mu g/mL, and 4, 3.3 x 10(-3) mu g/mL) against murine P388 lymphotytic leukemia.