BIOACTIVE ENT-KAURENE DITERPENOIDS FROM ANNONA-SENEGALENSIS

Authors
FATOPE MO AUDU OT TAKEDA Y ZENG L SHI G SHIMADA H MCLAUGHLIN JL
Citation
Mo. Fatope et al., BIOACTIVE ENT-KAURENE DITERPENOIDS FROM ANNONA-SENEGALENSIS, Journal of natural products, 59(3), 1996, pp. 301-303
Citations number
30
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
59
Issue
3
Year of publication
1996
Pages
301 - 303
Database
ISI
SICI code
0163-3864(1996)59:3<301:BEDFA>2.0.ZU;2-O
Abstract
Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED(50) 1 .0 mu g/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (pro state cancer) cells but with weaker potencies (ED(50) 17-18 mu g/mL). The structure of the new compound, 3, was deduced from spectral eviden ce.