KALLIKREIN AND SALIVARY SECRETION IN RATS DURING HEAT EXPOSURE

RP 67580, a NK1 receptor antagonist, inhibited the sialogogic effect o f Substance P (SP). Heat-induced salivation was indirectly measured th rough the changes in body weight. Thermolytic salivation was reduced b y atropine and RP 67580 and thus would be mainly controlled by acetylc holine and tachykinins. This salivation was associated with a large de pletion of kallikrein in submaxillary glands. This depletion was not i nhibited by atropine and RP 67580. Feeding has been reported to reduce amylase activity in parotid glands but did not modify the kallikrein content in submaxillary glands. Heat exposure did not modify amylase a ctivity. There is a dissociation between the releases of amylase and k allikrein from salivary glands.