S. Abdallah et al., SYNTHESIS AND ANTIPLATELET ACTIVITY OF 1-TERT-BUTYLAMINO-3-(3-THIENYLOXY)-2-PROPANOLS, Archiv der pharmazie, 329(4), 1996, pp. 216-222
The synthesis of new 1-tert-butylamino-3-(3-thienyloxy)-2-propanols by
two alternative methods is described. Their initial antiplatelet acti
vity evaluation against ADP, adrenaline, and collagen is reported, and
the preliminary structure-activity relationships are established. The
appropriateness of further pharmacological investigations, especially
for the best compound of the series 1f, is indicated.