SYNTHESIS AND ANTIPLATELET ACTIVITY OF 1-TERT-BUTYLAMINO-3-(3-THIENYLOXY)-2-PROPANOLS

Authors
ABDALLAH S DARIAS V DONOSO R DEURRIES PJ LISSAVETZKY J
Citation
S. Abdallah et al., SYNTHESIS AND ANTIPLATELET ACTIVITY OF 1-TERT-BUTYLAMINO-3-(3-THIENYLOXY)-2-PROPANOLS, Archiv der pharmazie, 329(4), 1996, pp. 216-222
Citations number
22
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
329
Issue
4
Year of publication
1996
Pages
216 - 222
Database
ISI
SICI code
0365-6233(1996)329:4<216:SAAAO1>2.0.ZU;2-#
Abstract
The synthesis of new 1-tert-butylamino-3-(3-thienyloxy)-2-propanols by two alternative methods is described. Their initial antiplatelet acti vity evaluation against ADP, adrenaline, and collagen is reported, and the preliminary structure-activity relationships are established. The appropriateness of further pharmacological investigations, especially for the best compound of the series 1f, is indicated.