HEPATOPROTECTIVE EFFECTS OF PANAX NOTOGINSENG - GINSENOSIDE-RE AND GINSENOSIDE-RG(1) AS ITS ACTIVE CONSTITUENTS IN D-GALACTOSAMINE LIPOPOLYSACCHARIDE-INDUCED LIVER-INJURY/

Authors
PRASAIN JK KADOTA S BASNET P HASE K NAMBA T
Citation
Jk. Prasain et al., HEPATOPROTECTIVE EFFECTS OF PANAX NOTOGINSENG - GINSENOSIDE-RE AND GINSENOSIDE-RG(1) AS ITS ACTIVE CONSTITUENTS IN D-GALACTOSAMINE LIPOPOLYSACCHARIDE-INDUCED LIVER-INJURY/, Phytomedicine, 2(4), 1996, pp. 297-303
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Phytomedicine → ACNP
ISSN journal
09447113
Volume
2
Issue
4
Year of publication
1996
Pages
297 - 303
Database
ISI
SICI code
0944-7113(1996)2:4<297:HEOPN->2.0.ZU;2-G
Abstract
The hepatoprotective effects of the methanol and water extracts of the roots of Panax notoginseng were studied on various animal models. The methanol and water extracts of P. notoginseng showed a significant ac tivity in carbon tetrachloride-induced liver injury in rats. However, the methanol extract was found to be more active. The hepatoprotective effects of the methanol extract was further evaluated using D-galacto samine as well as heat-killed Propionibacterium acnes/lipopolysacchari de-induced liver injury models. Two major isolates from the methanol e xtract, ginsenosides-lie and -Rg(1), showed a significant hepatoprotec tive effect on D-galactosamine/lipopolysaccharide-induced liver injury in mice.