ANGIOTENSIN-CONVERTING ENZYME (ACE) INHIBITORY FLAVONOIDS FROM ERYTHROXYLUM-LAURIFOLIUM

Authors
HANSEN K ADSERSEN A SMITT UW NYMAN U CHRISTENSEN SB SCHWARTNER C WAGNER H
Citation
K. Hansen et al., ANGIOTENSIN-CONVERTING ENZYME (ACE) INHIBITORY FLAVONOIDS FROM ERYTHROXYLUM-LAURIFOLIUM, Phytomedicine, 2(4), 1996, pp. 313-317
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Phytomedicine → ACNP
ISSN journal
09447113
Volume
2
Issue
4
Year of publication
1996
Pages
313 - 317
Database
ISI
SICI code
0944-7113(1996)2:4<313:AE(IFF>2.0.ZU;2-J
Abstract
In our screening program for antihypertensive properties of plants in traditional use, the 99% ethanol extract of Erythroxylum laurifolium l eaves showed interesting angiotensin converting enzyme (ACE) inhibitor y activity. The activity was found to be due to proanthocyanidins or c ondensed tannins and the flavonoids quercetin-3-O-rhamnoside (quercitr in) (IC50 = 0.67 mM) and kaempferol-3-O-rhamnoside (afzelin) (IC50 = 2 .8 mM). In addition, quercitrin with afzelin demonstrated in vitro syn ergistic ACE inhibitory activity.