RUMBRIN, A NEW CYTOPROTECTIVE SUBSTANCE PRODUCED BY AUXARTHRON-UMBRINUM .1. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL-ACTIVITIES

Authors
YAMAGISHI Y MATSUOKA M ODAGAWA A KATO S SHINDO K MOCHIZUKI J
Citation
Y. Yamagishi et al., RUMBRIN, A NEW CYTOPROTECTIVE SUBSTANCE PRODUCED BY AUXARTHRON-UMBRINUM .1. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 46(6), 1993, pp. 884-887
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
6
Year of publication
1993
Pages
884 - 887
Database
ISI
SICI code
0021-8820(1993)46:6<884:RANCSP>2.0.ZU;2-U
Abstract
Rumbrin has been isolated from a fungus, Auxarthron umbrinum, by a scr eening program designed to find microorganism-produced cytoprotective substances. It was purified by use of column chromatography on silica gel, reversed phase HPLC and then isolated as fine red needles. Rumbri n prevented cell death caused by calcium overload and exhibited a pote nt inhibitory activity against lipid peroxidation.