PYRROLOSTATIN, A NOVEL LIPID-PEROXIDATION INHIBITOR FROM STREPTOMYCES-CHRESTOMYCETICUS - TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES

Authors
KATO S SHINDO K KAWAI H ODAGAWA A MATSUOKA M MOCHIZUKI J
Citation
S. Kato et al., PYRROLOSTATIN, A NOVEL LIPID-PEROXIDATION INHIBITOR FROM STREPTOMYCES-CHRESTOMYCETICUS - TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES, Journal of antibiotics, 46(6), 1993, pp. 892-899
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
6
Year of publication
1993
Pages
892 - 899
Database
ISI
SICI code
0021-8820(1993)46:6<892:PANLIF>2.0.ZU;2-7
Abstract
Pyrrolostatin, a new lipid peroxidation inhibitor, was isolated from t he culture of Streptomyces chrestomyceticus EC40. The structure was de termined to be 4-geranylpyrrole-2-carboxylic acid on the basis of its spectroscopic and physico-chemical properties. Pyrrolostatin inhibited lipid peroxidation in rat brain homogenate.