LAGUNAMYCIN, A NOVEL 5-LIPOXYGENASE INHIBITOR .1. TAXONOMY, FERMENTATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL CHARACTERISTICS

Authors
NIHEI Y HASEGAWA M SUZUKI K YAMAMOTO S HANADA M FURUMAI T FUKAGAWA Y OKI T
Citation
Y. Nihei et al., LAGUNAMYCIN, A NOVEL 5-LIPOXYGENASE INHIBITOR .1. TAXONOMY, FERMENTATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL CHARACTERISTICS, Journal of antibiotics, 46(6), 1993, pp. 900-907
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
6
Year of publication
1993
Pages
900 - 907
Database
ISI
SICI code
0021-8820(1993)46:6<900:LAN5I.>2.0.ZU;2-O
Abstract
Lagunamycin. a novel 5-lipoxygenase inhibitor, was isolated from the c ulture broth of Streptomyces sp. AA0310. This compound showed potent r at 5-lipoxygenase inhibitory activity (IC50 6.08 muM) without lipid pe roxidation.