BEQUINOSTATIN-A AND BEQUINOSTATIN-B, NEW INHIBITORS OF GLUTATHIONE-S-TRANSFERASE, PRODUCED BY STREPTOMYCES SP MI384-DF12 - PRODUCTION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL-ACTIVITIES

Authors
AOYAMA T KOJIMA F ABE F MURAOKA Y NAGANAWA H TAKEUCHI T AOYAGI T
Citation
T. Aoyama et al., BEQUINOSTATIN-A AND BEQUINOSTATIN-B, NEW INHIBITORS OF GLUTATHIONE-S-TRANSFERASE, PRODUCED BY STREPTOMYCES SP MI384-DF12 - PRODUCTION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 46(6), 1993, pp. 914-920
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
6
Year of publication
1993
Pages
914 - 920
Database
ISI
SICI code
0021-8820(1993)46:6<914:BABNIO>2.0.ZU;2-L
Abstract
New benzo[a]naphthacenequinone metabolites, designated bequinostatins A and B, have been isolated from the culture broth of the benastatin-p roducing strain Streptomyces sp. MI384-DF12. The structures of bequino statins A and B were determined by spectral analyses to be ,13-dioxo-3 -pentylbenzo[a]naphthacene-2-carboxylic acid and 2-decarboxybequinosta tin A, respectively. Bequinostatin A showed considerable inhibitory-ac tivity against human pi class glutathione S-transferase (GST pi).