MICROBIAL SYNTHESIS OF (-)METHYL 4-CHLORO-4,4-DIFLUORO-3-HYDROXYBUTANOATE()METHYL AND ()

Authors
FORNI A MORETTI I PRATI F TORRE G
Citation
A. Forni et al., MICROBIAL SYNTHESIS OF (-)METHYL 4-CHLORO-4,4-DIFLUORO-3-HYDROXYBUTANOATE()METHYL AND (), Journal of molecular catalysis. A, Chemical, 107(1-3), 1996, pp. 405-407
Citations number
6
Categorie Soggetti
Chemistry Physical
Journal title
Journal of molecular catalysis. A, Chemical → ACNP
ISSN journal
13811169
Volume
107
Issue
1-3
Year of publication
1996
Pages
405 - 407
Database
ISI
SICI code
1381-1169(1996)107:1-3<405:MSO(4>2.0.ZU;2-9
Abstract
Microbial reduction with baker's yeast or Aspergillus niger of methyl 4-chloro-4,4-difluoro-3-oxobutanoate 1 afforded the optically active m ethyl(-)-4-chloro-4,4-difluoro-3-hydroxybutanoate 2. When yeast reduct ion was carried out in the presence of allyl bromide the optically act ive methyl (+)-4-chloro-4,4-difluoro-3-hydroxybutanoate 2 was obtained .