CARBONIC-ANHYDRASE INHIBITORS .36. INHIBITION OF ISOZYME-I AND ISOZYME-II WITH SCHIFF-BASES DERIVED FROM CHALKONES AND AROMATIC HETEROCYCLIC SULFONAMIDES/

Authors
SUPURAN CT POPESCU A ILISIU M COSTANDACHE A BANCIU MD
Citation
Ct. Supuran et al., CARBONIC-ANHYDRASE INHIBITORS .36. INHIBITION OF ISOZYME-I AND ISOZYME-II WITH SCHIFF-BASES DERIVED FROM CHALKONES AND AROMATIC HETEROCYCLIC SULFONAMIDES/, European journal of medicinal chemistry, 31(6), 1996, pp. 439-447
Citations number
31
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
31
Issue
6
Year of publication
1996
Pages
439 - 447
Database
ISI
SICI code
0223-5234(1996)31:6<439:CI.IOI>2.0.ZU;2-O
Abstract
A series of 27 Schiff bases was prepared by reaction of chalkones with sulfanilamide and 5-amino-1,3,4-thiadiazole-2-sulfonamide. The new co mpounds were characterized by analysis and standard physico-chemical m ethods. They possess good inhibitory properties towards isozymes I and II of carbonic anhydrase. Structure-activity effects in this series o f inhibitors are also discussed.