SOLUTION-PHASE SYNTHESIS IN COMBINATORIAL CHEMISTRY - APPLICATIONS INDRUG DISCOVERY

The application of combinatorial chemistry principles to produce libra ries of compounds, together with effective use of high-throughput biol ogical screening, is sei to revolutionize the way in which chemical le ads for drug discovery programmes are generated and evaluated. In th i s overview, solution-phase synthesis is compared and contrasted with s olid-phase synthesis, which remains the method of choice for most comb inatorial library work. The author discusses a variety of specific app roaches from different groups exemplifying the potential of solution-p hase work.