5-LIPOXYGENASE INHIBITION BY ACETYL-11-KETO-BETA-BOSWELLIC ACID (AKBA) BY A NOVEL MECHANISM

Authors
SAFAYHI H SAILER ER AMMON HPT
Citation
H. Safayhi et al., 5-LIPOXYGENASE INHIBITION BY ACETYL-11-KETO-BETA-BOSWELLIC ACID (AKBA) BY A NOVEL MECHANISM, Phytomedicine, 3(1), 1996, pp. 71-72
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Phytomedicine → ACNP
ISSN journal
09447113
Volume
3
Issue
1
Year of publication
1996
Pages
71 - 72
Database
ISI
SICI code
0944-7113(1996)3:1<71:5IBAA(>2.0.ZU;2-G
Abstract
Acetyl-11-keto-beta-boswellic acid (AKAB) from Boswellia serrata and B . carteuii acts directly on purified 5-lipoxygenase of human blood leu kocytes at a selective site for pentacyclic triterpenes that is differ ent from the arachidonate substrate binding site. The pentacyclic trit erpene ring is crucial for binding to the enzyme, whereas functional g roups (11-keto function in addition to a hydrophilic group on C4 of ri ng A) are essential for the 5-lipoxygenase activity.