EFFECTS OF BOSWELLIC-ACID OF BOSWELLIA-SERRATA AND OTHER TRITERPENIC ACIDS ON THE COMPLEMENT-SYSTEM

Authors
KNAUS U WAGNER H
Citation
U. Knaus et H. Wagner, EFFECTS OF BOSWELLIC-ACID OF BOSWELLIA-SERRATA AND OTHER TRITERPENIC ACIDS ON THE COMPLEMENT-SYSTEM, Phytomedicine, 3(1), 1996, pp. 77-80
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Phytomedicine → ACNP
ISSN journal
09447113
Volume
3
Issue
1
Year of publication
1996
Pages
77 - 80
Database
ISI
SICI code
0944-7113(1996)3:1<77:EOBOBA>2.0.ZU;2-I
Abstract
beta-boswellic acid (BA), one major constituent of the resin of Boswel lia serrata and other triterpenic acids of plant origin (crataegolic-, ursolic-, oleanolic- and glycyrrhetic acid) were found to possess ant i-complementary activity in the classical and in the alternative compl ement pathway. Significant reduction of immunohemolysis in vitro was o bserved at BA concentrations between 0.005-0.1 mM with an IC50 value o f about 10 mu mol/1.