TOXICITY AND SAFETY EVALUATION OF BOSWELLIC ACIDS

The acute, sub-acute and chronic toxicity studies on boswellic acids ( BAs) were carried out on mice, rats and monkeys. BAs did not cause any mortality in rats and mice when administered orally and intraperitone ally in doses up to 2 g/kg. Daily oral administration of BAs in three doses (low and very high) to rats and monkeys revealed no significant changes in general behaviour, or clinical, haematological, biochemical and pathological data. BAs, therefore, can be regarded as safe for cl inical studies.