EFFECT OF ASPIRIN-DIPYRIDAMOLE AND HEPARIN AND THEIR COMBINATION ON VENOUS THROMBOSIS IN HYPERCOAGULABLE OR THROMBOTIC ANIMALS

Epsilon-amino-caproic acid (EACA) induces a clinically-useful anti-hae morrhagic, mildly thrombotic state while ellagic acid (EA) induces a s evere hypercoagulable one. Reversal of these states may on occasion be necessary. The effectiveness of the antiplatelet drugs, aspirin and d ipyridamole (ASA/D), in reducing thrombus weight was studied in normoc oagulable animals and animals made hypercoagulable with EACA (333 mg/k g) or EA (1.2 mg/kg). Heparin (114 iu/kg) was tested in the EACA group , both alone and in combination with ASA/D. Thrombogenicity was measur ed by weight formed on intravenous platinum wire in one hour. In normo coagulable animals, ASA/D reduced thrombus by 32%. Ellagic acid treble d mean thrombus weight and ASA/D reduced this by 49%, but did not rest ore normality. EACA increased mean thrombosis by one sixth. Treatment with heparin reduced this by 48% to a level well below that of untreat ed animals. Addition of a single dose of aspirin/dipyridamole to the h eparin regime, reduced thrombosis by a further 31%, reaching to 21% of control thrombus. The results were statistically significant. Kaolin- activated blood clotting time was shortened by EA, but EACA had little effect on it, while ASA/D slightly and heparin markedly lengthened it .