REPORT OF A COMPLEX KARYOTYPE IN RECURRENT METASTATIC FIBROLAMELLAR HEPATOCELLULAR-CARCINOMA AND A REVIEW OF HEPATOCELLULAR-CARCINOMA CYTOGENETICS

Metastatic fibrolamellar hepatocellular carcinoma (HCC) was detected i n the abdominal lymph nodes of an adolescent male after resection of t he primary tumor. No dividing cells were isolated from attempted cytog enetic studies of the primary tumor. However, cytogenetic analysis of lymph node metastases detected 9 and 12 months after partial hepatecto my revealed abnormal hypertriploid karyotypes, with a suggestion of cl onal evolution, 62-92 [3n], XX, -Y, +3, +6, +6, +7, +7, +8, +10, +13, +15, +16, +20, -21, -22, +mar1x2, +mar[cp6]/46, XY[8] and 78[3n], XX, -Y, der(1)t(1;1)(p36,1;q21), +4, +6, +6, +7, +7, i(8)(q10), +10, +15, +20, -21, -22, +mar2[3]/46, XY[17], respectively. Karyotypes of this v ariant of HCC have not been reported previously. The cytogenetics of H CC are reviewed.