Citation
Ja. Hutter et al., ANTIINFLAMMATORY C-GLUCOSYL CHROMONE FROM ALOE-BARBADENSIS, Journal of natural products, 59(5), 1996, pp. 541-543
Citations number
3
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
ISSN journal
01633864
Volume
59
Issue
5
Year of publication
1996
Pages
541 - 543
Database
ISI
SICI code
0163-3864(1996)59:5<541:ACCFA>2.0.ZU;2-G
Abstract
A new antiinflammatory agent identified as 8-[C-beta-D-[2-O-(E)-cinnam
oyl] ranosyl]-2[(R)-2-hydroxypropyl]-7-methoxy-5-methyl (1) has been i
solated from Aloe barbadensis Miller. At a dose of 200 mu g/mouse ear,
1 exhibited topical antiinflammatory activity equivalent to 200 mu g/
ear of hydrocortisone. There was no reduction in thymus weight caused
by treatment with 1 for any of the doses tested, while 200 mu g/ear of
hydrocortisone resulted in a 50% decrease in thymus weight.