ROLLINECIN-A AND ROLLINECIN-B - 2 NEW BIOACTIVE ANNONACEOUS ACETOGENINS FROM ROLLINIA-MUCOSA

Authors
SHI G YE Q HE K MCLAUGHLIN JL MACDOUGAL JM
Citation
G. Shi et al., ROLLINECIN-A AND ROLLINECIN-B - 2 NEW BIOACTIVE ANNONACEOUS ACETOGENINS FROM ROLLINIA-MUCOSA, Journal of natural products, 59(5), 1996, pp. 548-551
Citations number
16
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
59
Issue
5
Year of publication
1996
Pages
548 - 551
Database
ISI
SICI code
0163-3864(1996)59:5<548:RAR-2N>2.0.ZU;2-6
Abstract
Two new mono-THF ring acetogenins, rollinecins A (1) and B (2), were i solated from the partitioned ethanolic extracts of the leaves of Rolli nia mucosa (Annonaceae) by activity-directed fractionation. 1 and 2 ar e epimeric at the C-14 carbinol stereocenter. Their absolute stereoche mical structures were solved by preparing their respective per-Mosher ester derivatives. 1 and 2 showed equivalent and selective in vitro ac tivities against several human solid tumor cell lines.