SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF IAZOL-5-YLMETHOXY)-3-PHENYL-1-BENZOPYRAN-2(H)-ONES

Several substituted 4-alkyl-7-(4-amino/H-3-mercapto-1, 2, iazol-5-ylme thoxy)-3-phenyl-1-benzopyran-2(H)-ones (13-15 and 19-21) have been syn thesized and tested for their in vitro growth inhibitory and spore ger mination inhibitory activities against several phytopathogenic fungi a nd bacteria. The intermediate l-4-(n)-propyl-2-oxo-2H-1-benzopyranyl-7 -oxyacetic acid:hydrazide (9) and 14 have been found to be the most ac tive compounds against R. solani and P. recondita uredo spores at 6.25 mu g/mL and 3.125 mu g/mL concentrations, respectively. Compounds 12, 14 and 15 exhibit significant activity against E. coli with MIC value at 6.25 mu g/mL concentration.