Vk. Ahluwalia et M. Bala, A FACILE ONE-POT SYNTHESIS OF SOME NEW DERIVATIVES OF PYRANO[2,3-D]PYRIMIDINES AS POTENTIAL ANTIBACTERIAL AND ANTIFUNGAL AGENTS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 35(7), 1996, pp. 742-744
Claisen condensation of 3,4-tetrahydro-6-hydroxy-4-oxo-2-thioxopyrimid
ines (1a-f) has been carried out using diethylcarbonate, as one carbon
synthon, in the presence of pulverised sodium to yield ethyl 2-thioxo
-7H-pyrano[2,3-d]pyrimidine-6-carboxylates (2a-f). All the compounds h
ave been screened for their antibacterial, antimycobacterial and antif
ungal activities.