L. Vizzotto et al., EFFECT OF TESTOSTERONE ON PURINE METABOLISM AND MORPHOMETRIC PARAMETERS IN THE RAT-LIVER, Molecular and cellular endocrinology, 119(2), 1996, pp. 123-127
The effect of testosterone on the morphology and biochemistry of adult
castrated rat liver is described. Castration decreases mean weight an
d volume of hepatocytes, volume and surface area of sinusoidal lumen,
and apparently increases cell number per g of tissue. These variations
indicate cell distress. Testosterone administration restored sinusoid
al volume and surface area, indicating a true hyperplastic response an
d improved trophic conditions. Acid soluble nucleotides, RNA and DNA c
ontent were lower after castration, being partially restored after tes
tosterone treatment. This restoration, however, was only statistically
significant for total guanylate. We concluded that testosterone defic
iency and administration exerts a specific effect on the liver in term
s of morphological and biochemical changes. Purine nucleotide metaboli
sm is probably the first target of hormonal action, since its changes
are the most significant and useful to explain all the other observati
ons.