NEW PERSPECTIVES IN LEAD GENERATION .2. EVALUATING MOLECULAR DIVERSITY

Authors
ASHTON MJ JAYE MC MASON JS
Citation
Mj. Ashton et al., NEW PERSPECTIVES IN LEAD GENERATION .2. EVALUATING MOLECULAR DIVERSITY, Drug discovery today, 1(2), 1996, pp. 71-78
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
Drug discovery today → ACNP
ISSN journal
13596446
Volume
1
Issue
2
Year of publication
1996
Pages
71 - 78
Database
ISI
SICI code
1359-6446(1996)1:2<71:NPILG.>2.0.ZU;2-Y
Abstract
The identification of biological targets was discussed in part I. The next major hurdle is to discover a compound that selectively interacts with the target. In the second part of a two-part article, the author s focus on the problem of how to define and measure diversity within a nd between compound libraries in order to optimize molecular diversity for lead generation.