STRAIN DISTRIBUTION PATTERNS FOR GENETIC-MARKERS IN THE LSXSS RECOMBINANT-INBRED SERIES

We present the strain distribution patterns (SDPs) of 118 SSLP markers and three pigmentation genes that have been characterized in 27 strai ns from the LSXSS RT series. This coarse map provides a resource for l inkage studies of phenotypes that are heritable in the LSXSS RI series . The LSXSS recombinant inbred (RI) strains were derived from the Long -Sleep (LS) and Short-Sleep (SS) selected lines of mice that were sele cted for differential sensitivity to ethanol but are also differential ly sensitive to a variety of other alcohols, barbiturates, sedative hy pnotics, and general anesthetics. Since the parents were not inbred, t wo atypical factors are present in these SDPs. First, more than two al leles are frequently found in these RIs, and second, some alleles can be uniquely associated with one or the other parent while other allele s may be found in both parental lines. To validate the markers found i n the parental line, we genotyped all parental mice from one generatio n of both the LS and SS lines, thus leading to a set of marker SDPs th at are useful for further phenotypic association and identification of provisional QTLs.