DIFFERENT ALLELIC PATTERNS AT CHROMOSOME 11Q13 IN PAIRED ALD ALDOSTERONE-PRODUCING TUMORS AND BLOOD DNA

1. We previously reported loss of heterozygosity (LOH) at region q13 o f chromosome 11 in five aldosterone-producing tumours (APT) using rest riction fragment length polymorphism (RFLP) analysis, including two fr om patients with familial hyperaldosteronism. 2. In the present study, microsatellite markers were used to examine 33 informative paired blo od and tumour DNA samples from patients with APT for LOH at three loci that map to chromosome 11q13. 3. LOH at one or more loci was detected in seven (21.2%) tumour DNA samples, 4. This study provides further s upport that mutations at 11q13 may be involved in the underlying patho physiology of aldosterone-producing tumours of the adrenal cortex.