ALPHA-SUBUNIT OF CAM-KII INCREASES GLYCINE CURRENTS IN ACUTELY ISOLATED RAT SPINAL NEURONS

1. Here we report that in acutely isolated rat spinal dorsal horn neur ons, the glycine receptor can be regulated by exogenous calcium/calmod ulin-dependent protein kinase II (CaM-KII). Intracellularly applied, t he alpha-subunit of CaM-KII enhanced glycine receptor-activated curren t recorded with the use of the whole cell patch-clamp technique. This result suggests that the function of glycine receptor is modulated by CaM-KII, but the cellular mechanism underlying the enhancement of glyc ine receptor-activated current is still unknown.