EXPERIMENTAL AND COMPUTER-SIMULATION STUDIES OF SOLUTE-SOLUTE INTERACTIONS IN LIQUID-CHROMATOGRAPHY

Authors
LUKULAY PH MCGUFFIN VL
Citation
Ph. Lukulay et Vl. Mcguffin, EXPERIMENTAL AND COMPUTER-SIMULATION STUDIES OF SOLUTE-SOLUTE INTERACTIONS IN LIQUID-CHROMATOGRAPHY, Journal of liquid chromatography & related technologies, 19(13), 1996, pp. 2039-2058
Citations number
52
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Journal of liquid chromatography & related technologies → ACNP
ISSN journal
10826076
Volume
19
Issue
13
Year of publication
1996
Pages
2039 - 2058
Database
ISI
SICI code
1082-6076(1996)19:13<2039:EACSOS>2.0.ZU;2-O
Abstract
Solute-solute interactions, due to self-association as well as mixed a ssociation, are shown to arise for the steroids cortisone, tetrahydroc ortisol, tetrahydrocortisone, and methylprednisolone. From molecular m echanics and dynamics simulations, these interactions appear to be dri ven by strong electrostatic and hydrogen bonding forces. These interac tions have a significant effect on solute retention and dispersion beh avior under routine operating conditions in reverse-phase liquid chrom atography.