QUEUING MODELS OF POTENTIALLY LETHAL DAMAGE REPAIR IN IRRADIATED-CELLS

Citation
Em. Myasnikova et al., QUEUING MODELS OF POTENTIALLY LETHAL DAMAGE REPAIR IN IRRADIATED-CELLS, Mathematical biosciences, 135(1), 1996, pp. 85-109
Citations number
35
Categorie Soggetti
Mathematical Methods, Biology & Medicine","Mathematics, Miscellaneous","Biology Miscellaneous
Journal title
ISSN journal
00255564
Volume
135
Issue
1
Year of publication
1996
Pages
85 - 109
Database
ISI
SICI code
0025-5564(1996)135:1<85:QMOPLD>2.0.ZU;2-D
Abstract
Some of the ideas arising in queueing theory are applied to describe t he repair mechanisms responsible for recovery of cells from potentiall y lethal radiation damage. Two alternative versions are presented of a queueing model of damage repair after a single dose of irradiation. T he first version represents a linear misrepair model, and the second i nvokes the idea of spontaneous lesion fixation. They are pieced togeth er in the third model, allowing for both mechanisms. The consistency o f the proposed models with published experimental data is tested.