The chapter provides a personal and anecdotal account of the author's
attempts to keep the horizons of advancing science in sight. It sketch
es his background to entering science and chronicles various episodes
across fifty years in research. Milestones are noted on the author's j
ourney from his structural studies on colchicine, griseofulvin, and gi
bberellic acid to the isolation, analysis, biosynthesis, and molecular
biology of plant gibberellins. The author discusses his personal and
professional interactions with plant physiologists and plant biochemis
ts over the years. Philosophical observations are offered on some of t
he attributes important to conducting research and on changing attitud
es toward research.