SYNTHESIS AND HPLC-SEPARATION OF ATROPISO MERIC AND CENTRAL CHIRAL 3-ARYL-2-MERCAPTO-4(3H)-QUINAZOLINONE AND 3-ARYL-2-ALKYLTHIO-4(3H)-QUINAZOLINONE DERIVATIVES ON CHIRAL STATIONARY PHASES .2. CHIRAL ENANTIOMERIC SEPARATION

Authors
JIRA T SCHOPPLICH C BUNKE A LEUTHOLD J JUNGHANEL J THEISS R KOTTKE K BESCH A BEYRICH T
Citation
T. Jira et al., SYNTHESIS AND HPLC-SEPARATION OF ATROPISO MERIC AND CENTRAL CHIRAL 3-ARYL-2-MERCAPTO-4(3H)-QUINAZOLINONE AND 3-ARYL-2-ALKYLTHIO-4(3H)-QUINAZOLINONE DERIVATIVES ON CHIRAL STATIONARY PHASES .2. CHIRAL ENANTIOMERIC SEPARATION, Die Pharmazie, 51(6), 1996, pp. 379-386
Citations number
26
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
51
Issue
6
Year of publication
1996
Pages
379 - 386
Database
ISI
SICI code
0031-7144(1996)51:6<379:SAHOAM>2.0.ZU;2-L
Abstract
In this paper, the stereochemical resolution of atropisomeric and cent ral chiral 3-aryl-2-mercapto-, 3-aryl-2-alkylthio-4(3H)-quinazolinones and their derivatives with chiral side chain on chiral stationary pha ses (CSP) are described. These CSP are a Pirkle phase (ChiralD-DPG=Si 100), a synthetic polymer (ChiraSpher(R)) and various types of cellulo se (Chiralcel(R)OD-H, OD-R, Chiralcel(R)OB-H and cellulose triacetate (TAC)) and other CSP. The cellulose phases gave the best results. The effects of the position and type of the substituent as well as the eff ect of the temperature and mobile phase composition on the chromatogra phic separation are described.