SYNTHESIS AND HPLC-SEPARATION OF ATROPISO MERIC AND CENTRAL CHIRAL 3-ARYL-2-MERCAPTO-4(3H)-QUINAZOLINONE AND 3-ARYL-2-ALKYLTHIO-4(3H)-QUINAZOLINONE DERIVATIVES ON CHIRAL STATIONARY PHASES .2. CHIRAL ENANTIOMERIC SEPARATION
T. Jira et al., SYNTHESIS AND HPLC-SEPARATION OF ATROPISO MERIC AND CENTRAL CHIRAL 3-ARYL-2-MERCAPTO-4(3H)-QUINAZOLINONE AND 3-ARYL-2-ALKYLTHIO-4(3H)-QUINAZOLINONE DERIVATIVES ON CHIRAL STATIONARY PHASES .2. CHIRAL ENANTIOMERIC SEPARATION, Die Pharmazie, 51(6), 1996, pp. 379-386
In this paper, the stereochemical resolution of atropisomeric and cent
ral chiral 3-aryl-2-mercapto-, 3-aryl-2-alkylthio-4(3H)-quinazolinones
and their derivatives with chiral side chain on chiral stationary pha
ses (CSP) are described. These CSP are a Pirkle phase (ChiralD-DPG=Si
100), a synthetic polymer (ChiraSpher(R)) and various types of cellulo
se (Chiralcel(R)OD-H, OD-R, Chiralcel(R)OB-H and cellulose triacetate
(TAC)) and other CSP. The cellulose phases gave the best results. The
effects of the position and type of the substituent as well as the eff
ect of the temperature and mobile phase composition on the chromatogra
phic separation are described.